J Peds Vol 156 No.4- interesting association between PET and BPD is brought up. Placenta is in a anti-angiogenic condition in PET and similar condition may exist in fetal lung as well disrupting angiogenesis in the lung --> BPD. This may be more common in growth restricted than in AGA preterms. However, this study lacks many important postnatal variables to conclude strongly. This study lays indirect role for nitric oxide post natally and vascular endothelial growth factor for antenatal use.
A working hypothesis is that disruption of angiogenesis during lung development impairs alveolarization contributing to BPD and that preservation of vascular growth and endothelial survival promotes growth and sustains the architecture of the distal airspace.[10] Withdrawal of angiogenic growth factors (such as vascular endothelial growth factor [VEGF} and nitric oxide) disrupts lung vascular growth and impairs alveolarization in infant rats
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