In a small study, researchers have found improved outcomes at 18 months. 17 in prophylactic group (40mg/kg) 21 in the control group were followed up for neurological outcomes with whole body cooling.
Three infants in the prophylaxis group (15%) and 18 in the control group (82%) had seizures while they were in the NICU (p < 0.0001).
There was a trend towards other benefits. But it is a small study with no EEG in all patients. Hence, take it with a pinch of salt.
The study is in Jour. Pediatrics.
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