Monday, June 21, 2010

Topiramate-Neuroprotective in HIE?

Oral Topiramate in Neonates with Hypoxic Ischemic Encephalopathy Treated with Hypothermia: A Safety Study

http://www.jpeds.com/article/PIIS0022347610003197/abstract?rss=yes

Conclusion

Although the number of newborns in this study was limited, the short-term outcome and the safety data appear to support the evaluation of topiramate in clinical trials to explore its possible additive neuroprotective action.

Interesting. What is the mechanism of action? I will try and find out.

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