Friday, January 14, 2011

Oseltamivir-NICU experience

http://www.nature.com/jp/journal/vaop/ncurrent/full/jp2010159a.html
About 11 infants were treated for H1N1 and 21 were prophylaxed with Oseltamivir.
Age ranged from 2 days to 11.4 months (mean, 2.1 months). Corrected gestational age and weight at initiation of oseltamivir ranged from 32 to 86 weeks (mean, 41 weeks) and 775 to 8635g (mean, 3074g), respectively.

Conclusion:

Oseltamivir appears to be well tolerated in preterm and term neonates and infants with complex underlying conditions. More studies are needed to determine optimal dosing for treatment and prophylaxis in this vulnerable age group.

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