Inter-Alpha Inhibitor Protein Level in Neonates Predicts Necrotizing Enterocolitis

http://www.jpeds.com/article/S0022-3476%2810%2900394-X/abstract
This was a prospective observational study of neonates in the neonatal intensive care unit.

Results

Seventeen neonates had confirmed NEC, and 34 neonates had nonspecific abdominal disorders that improved rapidly. Gestational age, postnatal age, weight, sex, maternal obstetric variables, rupture of membranes, and mode of delivery did not differ between the two groups. Mean IaIp level was significantly lower in the NEC group compared with the control group (137 ± 38 mg/L; 95% confidence interval [CI], 118-157 mg/L vs 258 ± 53 mg/L; 95% CI, 238-277 mg/L; P <.0001).

Conclusions

The finding of significantly lower IaIp levels in neonates with NEC suggests that IaIp might be a useful, sensitive biomarker, allowing initiation of appropriate therapy
Looks promising.