Nasal high frequency percussive ventilation versus nasal continuous positive airway pressure in transient tachypnea of the newborn: A pilot randomized

Methods

A prospective, unmasked, randomized, controlled clinical trial was conducted in 46 eligible newborn infants who were hospitalized for TTN in the University Hospital of Bordeaux (France) between 2007 and 2009.

Results

In the NHFPV group the duration of TTN was half the time of NCPAP group (105 min ± 20 and 377 min ± 150, respectively; P  < 0.0001). There was a significant decrease in duration of oxygen supplementation in the NHFPV group (6.3 min ± 3.3) compared to the NCPAP group (19.1 min ± 8.1; P < 0.001), and a significant decrease in level of oxygen supplementation [(FiO₂—0.21)/time of O₂ therapy] in the NHFPV group (0.29 min⁻¹ ± 0.16) compared to the NCPAP group (0.46 min⁻¹ ± 0.50; P < 0.001). There was no complication and NHFPV was as well tolerated as NCPAP.

My Word: The results are statistically significant but not clinically relevant 6.3 minutes vs 19 minutes! Not for prime time yet.